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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ryanodine receptor 1
UniprotKB/SwissProt ID: P21817 (P21817)

Gene Name: RYR1

Organism: Homo sapiens (Human)

Function: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Sarcoplasmic reticulum membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001870 B30.2/SPRY
IPR043136 B30.2/SPRY_sf
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR015925 Ryanodine_IP3_receptor
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR048581 RYDR_Jsol
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
The S-nitrosylation sites of P21817
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1039 ATKRSNRDSL C QAVRTLLGYG  CCCCCCCCCE E EEECCCCHHH  2.56% 17071618
2 1302 LPVQFHQHFR C TAGATPLAPP  CCCCCCCCCE E EEECCCCHHH  2.75% 17071618
3 1590 QSERKNPAPQ C PPRLEMQMLM  CCCCCCCCCE E EEECCCCHHH  4.95% 17071618
4 2326 KGYPDIGWNP C GGERYLDFLR  CCCCCCCCCE E EEECCCCHHH  11.19% 17071618
5 2363 VVRLLIRKPE C FGPALRGEGG  CCCCCCCCCE E EEECCCCHHH  6.92% 17071618
6 252 RLVYYEGGAV C THARSLWRLE  CCCCCCCCCE E EEECCCCHHH  1.98% 17071618
7 314 SKAHTKATSF C FRISKEKLDV  CCCCCCCCCE E EEECCCCHHH  1.93% 17071618
8 3193 VEKLRPALGE C LARLAAAMPV  CCCCCCCCCE E EEECCCCHHH  3.23% 17071618
9 35 ATVLKEQLKL C LAAEGFGNRL  CCCCCCCCCE E EEECCCCHHH  2.02% 17071618
10 3635 SKQRRRAVVA C FRMTPLYNLP  CCCCCCCCCE E EEECCCCHHH  1.18% 17071618
15688001
11562475
12509428
11 810 KFLPPPGYAP C HEAVLPRERL  CCCCCCCCCE E EEECCCCHHH  3.26% 17071618
12 905 VRDDNKRLHP C LVDFHSLPEP  CCCCCCCCCE E EEECCCCHHH  3.94% 17071618