UniprotKB/SwissProt ID: P21457 (P21457)
Gene Name:
RCVRN
Organism: Bos taurus (Bovine)
Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (PubMed:1672047, PubMed:1672637). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (PubMed:12686556, PubMed:16675451, PubMed:1672047, PubMed:1672637, PubMed:17015448, PubMed:21299498, PubMed:8392055). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Photoreceptor outer segment membrane. Perikaryon
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