Protein Name:
V-type proton ATPase subunit B, brain isoform
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UniprotKB/SwissProt ID: P21281 (P21281)
Gene Name:
ATP6V1B2
Organism: Homo sapiens (Human)
Function: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Melanosome. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P21281
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
112 |
TSGIDAKKTS C EFTGDILRTP |
CHHHHHHCHH C CCCCCCCCCC |
6.37% |
2212679
37478858
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| 2 |
162 |
DIMGQPINPQ C RIYPEEMIQT |
CHHHHHHCHH C CCCCCCCCCC |
2.77% |
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| 3 |
207 |
LPHNEIAAQI C RQAGLVKKSK |
CHHHHHHCHH C CCCCCCCCCC |
1.43% |
37478858
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| 4 |
425 |
HADVSNQLYA C YAIGKDVQAM |
CHHHHHHCHH C CCCCCCCCCC |
1.17% |
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