UniprotKB/SwissProt ID: P20241 (P20241)
Gene Name:
Nrg
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for septate junctions. Septate junctions, which are the equivalent of vertebrate tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for formation of the hemolymph-brain barrier (the insect blood-brain barrier). Vital for embryonic development. Involved in the targeting for degradation or recycling of certain septate junction components, including kune and bou/boudin, by regulating their endocytosis (PubMed:28977027) May play a role in neural and glial cell adhesion in the developing embryo May be a more general cell adhesion molecule involved in non-neuronal tissues and imaginal disk morphogenesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell junction, septate junction
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