UniprotKB/SwissProt ID: P20155 (P20155)
Gene Name:
SPINK2
Organism: Homo sapiens (Human)
Function: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome
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