Protein Name:
Beta-hexosaminidase subunit beta
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UniprotKB/SwissProt ID: P20060 (P20060)
Gene Name:
Hexb
Organism: Mus musculus (Mouse)
Function: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (PubMed:8253842)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome. Cytoplasmic vesicle, secretory vesicle, Cortical granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P20060
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
288 |
GKGQKNLLTP C YNQKTKTQVF |
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| 2 |
530 |
IAAQPLYTGY C NYENKI---- |
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