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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Nucleolin

UniprotKB/SwissProt ID: P19338 (P19338)

Gene Name: NCL

Organism: Homo sapiens (Human)

Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus. Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR034230 Nucleolin_RRM1
IPR034233 Nucleolin_RRM2
IPR034234 Nucleolin_RRM3
IPR034235 Nucleolin_RRM4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk

The S-nitrosylation sites of P19338

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 543 FEDAKEALNS C NKREIEGRAI  CCCHHHCCCC C CCCCCCCCCC  7.28% 19483679