Protein Name:
Neurofilament heavy polypeptide
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UniprotKB/SwissProt ID: P19246 (P19246)
Gene Name:
Nefh
Organism: Mus musculus (Mouse)
Function: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, axon
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P19246
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
225 |
QKKAQALQEE C GYLRRHHQEE |
CCCCCCHHHH C CCCCCCCCCC |
4.23% |
22178444
22588120
19101475
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| 2 |
263 |
AQAEARDALK C DVTSALREIR |
CCCCCCHHHH C CCCCCCCCCC |
5.45% |
22178444
19101475
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| 3 |
409 |
AYRKLLEGEE C RIGFGPSPFS |
CCCCCCHHHH C CCCCCCCCCC |
3.15% |
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