Protein Name:
Guanine nucleotide-binding protein G(o) subunit alpha
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UniprotKB/SwissProt ID: P18872 (P18872)
Gene Name:
Gnao1
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:10926822). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:10926822). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:10926822). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:10926822). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:10926822). Signaling is mediated via effector proteins, such as adenylate cyclase (PubMed:10926822). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:10926822)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P18872
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
108 |
KERKTDSKMV C DVVSRMEDTE |
CCCCCCHHHH H HHHHHHHHHH |
2.69% |
24895380
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| 2 |
140 |
RLWGDSGIQE C FNRSREYQLN |
CCCCCCHHHH H HHHHHHHHHH |
1.78% |
24895380
22588120
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| 3 |
255 |
HESLMLFDSI C NNKFFIDTSI |
CCCCCCHHHH H HHHHHHHHHH |
5.48% |
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