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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA ligase 1

UniprotKB/SwissProt ID: P18858 (P18858)

Gene Name: LIG1

Organism: Homo sapiens (Human)

Function: DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050191 ATP-dep_DNA_ligase
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold

The S-nitrosylation sites of P18858

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 434 IDIIKGLFVA C RHSEARFIAR   
2 565 LKRFEEAAFT C EYKYDGQRAQ   
3 794 DEDSEELQAI C KLGTGFSDEE   
4 895 EQATTSAQVA C LYRKQSQIQN