UniprotKB/SwissProt ID: P18434 (P18434)
Gene Name:
ATP4B
Organism: Sus scrofa (Pig)
Function: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (PubMed:19387495, PubMed:29618813)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Cell membrane
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