UniprotKB/SwissProt ID: P18292 (P18292)
Gene Name:
F2
Organism: Rattus norvegicus (Rat)
Function: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (By similarity). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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