Protein Name:
Receptor-type tyrosine-protein phosphatase alpha
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UniprotKB/SwissProt ID: P18052 (P18052)
Gene Name:
Ptpra
Organism: Mus musculus (Mouse)
Function: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (PubMed:22801373). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (PubMed:22801373)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell junction, focal adhesion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P18052
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
457 |
MLKFLKKVKA C NPQYAGAIVV |
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| 2 |
770 |
SAGAGRTGTF C ALSTVLERVK |
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