Protein Name:
Tyrosine-protein phosphatase non-receptor type 1
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UniprotKB/SwissProt ID: P18031 (P18031)
Gene Name:
PTPN1
Organism: Homo sapiens (Human)
Function: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P18031
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
121 |
NRVMEKGSLK C AQYWPQKEEK |
CCHHHHHHHH C CCCCHHHHHH |
3.28% |
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| 2 |
215 |
SPEHGPVVVH C SAGIGRSGTF |
CCHHHHHHHH C CCCCHHHHHH |
1.69% |
22169477
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| 3 |
32 |
DIRHEASDFP C RVAKLPKNKN |
CCHHHHHHHH C CCCCHHHHHH |
5.73% |
22178444
19483679
22126794
18840608
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| 4 |
344 |
VKEETQEDKD C PIKEEKGSPL |
CCHHHHHHHH C CCCCHHHHHH |
4.65% |
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| 5 |
92 |
ILTQGPLPNT C GHFWEMVWEQ |
CCHHHHHHHH C CCCCHHHHHH |
5.18% |
22178444
18840608
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