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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit alpha
UniprotKB/SwissProt ID: P17987 (P17987)

Gene Name: TCP1

Organism: Homo sapiens (Human)

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/GroEL/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR053374 TCP-1_chaperonin
IPR054827 thermosome_alpha
The S-nitrosylation sites of P17987
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 147 IVNTDELGRD C LINAAKTSMS  CCCCCEECCC C CCCCCHHHHH  3.86% 22178444
19483679
18335467
2 218 SMLISGYALN C VVGSQGMPKR  CCCCCEECCC C CCCCCHHHHH  2.46%
3 236 PKRIVNAKIA C LDFSLQKTKM  CCCCCEECCC C CCCCCHHHHH  4.22% 19483679
4 296 ILTTGGIDDM C LKYFVEAGAM  CCCCCEECCC C CCCCCHHHHH  3.69%
5 357 QAEEVVQERI C DDELILIKNT  CCCCCEECCC C CCCCCHHHHH  7.26% 18335467
19483679
20140087
22178444
6 385 IILRGANDFM C DEMERSLHDA  CCCCCEECCC C CCCCCHHHHH  3.96% 37478858
7 397 EMERSLHDAL C VVKRVLESKS  CCCCCEECCC C CCCCCHHHHH  3.38% 19483679
2212679
37478858
8 76 EVEHPAAKVL C ELADLQDKEV  CCCCCEECCC C CCCCCHHHHH  4.51% 22178444
19483679
20140087