Protein Name:
ATP-dependent 6-phosphofructokinase, liver type
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UniprotKB/SwissProt ID: P17858 (P17858)
Gene Name:
PFKL
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P17858
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
170 |
GLVGSIDNDF C GTDMTIGTDS |
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| 2 |
334 |
LLEATPDTPA C VVTLSGNQSV |
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| 3 |
351 |
NQSVRLPLME C VQMTKEVQKA |
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| 4 |
630 |
QRGLVLRNEK C HDYYTTEFLY |
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| 5 |
708 |
RVFANAPDSA C VIGLKKKAVA |
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