Protein Name:
Calpain-2 catalytic subunit
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UniprotKB/SwissProt ID: P17655 (P17655)
Gene Name:
CAPN2
Organism: Homo sapiens (Human)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P17655
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
240 |
KALQKGSLLG C SIDITSAADS |
CCCHHHHHHH H HHHHHCCCCH |
3.04% |
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| 2 |
301 |
VEWTGRWNDN C PSWNTIDPEE |
CCCHHHHHHH H HHHHHCCCCH |
2.93% |
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| 3 |
341 |
FLRHYSRLEI C NLTPDTLTSD |
CCCHHHHHHH H HHHHHCCCCH |
2.2% |
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| 4 |
39 |
NQDYEALRNE C LEAGTLFQDP |
CCCHHHHHHH H HHHHHCCCCH |
4.8% |
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| 5 |
405 |
DEDEEDGESG C TFLVGLIQKH |
CCCHHHHHHH H HHHHHCCCCH |
3.19% |
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| 6 |
498 |
TFEPNKDGDF C IRVFSEKKAD |
CCCHHHHHHH H HHHHHCCCCH |
2% |
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| 7 |
577 |
IKSDGFSIET C KIMVDMLDSD |
CCCHHHHHHH H HHHHHCCCCH |
1.5% |
2212679
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| 8 |
640 |
ALEEAGFKMP C QLHQVIVARF |
CCCHHHHHHH H HHHHHCCCCH |
6.34% |
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| 9 |
82 |
GIEWKRPTEI C ADPQFIIGGA |
CCCHHHHHHH H HHHHHCCCCH |
2.6% |
2212679
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