UniprotKB/SwissProt ID: P17301 (P17301)
Gene Name:
ITGA2
Organism: Homo sapiens (Human)
Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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