Protein Name:
Aspartate aminotransferase, cytoplasmic
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UniprotKB/SwissProt ID: P17174 (P17174)
Gene Name:
GOT1
Organism: Homo sapiens (Human)
Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P17174
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
253 |
YFVSEGFEFF C AQSFSKNFGL |
CCCCCHHCCC C CCCCEEEEEE |
4.01% |
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| 2 |
46 |
LGVGAYRTDD C HPWVLPVVKK |
CCCCCHHCCC C CCCCEEEEEE |
4.64% |
19483679
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