UniprotKB/SwissProt ID: P16975 (P16975)
Gene Name:
Sparc
Organism: Rattus norvegicus (Rat)
Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane
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