Protein Name:
Ryanodine receptor 1
|
UniprotKB/SwissProt ID: P16960 (P16960)
Gene Name:
RYR1
Organism: Sus scrofa (Pig)
Function: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (By similarity). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Sarcoplasmic reticulum membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P16960
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
3631 |
SKQRRRAVVA C FRMTPLYNLP |
CCCCCCCCCC E EEEECCCCHH |
1.18% |
|
|
