UniprotKB/SwissProt ID: P16157 (P16157)
Gene Name:
ANK1
Organism: Homo sapiens (Human)
Function: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Sarcoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum
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