Protein Name:
Integrin beta-4
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UniprotKB/SwissProt ID: P16144 (P16144)
Gene Name:
ITGB4
Organism: Homo sapiens (Human)
Function: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell membrane. Cell junction, hemidesmosome
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Graphical Visualization of S-nitrosylation Sites:
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