UniprotKB/SwissProt ID: P15941 (P15941)
Gene Name:
MUC1
Organism: Homo sapiens (Human)
Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Secreted. Secreted. Secreted. Cell membrane. Cytoplasm. Nucleus
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