Protein Name:
Desmoplakin
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UniprotKB/SwissProt ID: P15924 (P15924)
Gene Name:
DSP
Organism: Homo sapiens (Human)
Function: Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, desmosome. Cell membrane. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P15924
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1052 |
RLARDANSEN C NKNKFLDQNL |
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| 2 |
1069 |
DQNLQKYQAE C SQFKAKLASL |
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| 3 |
110 |
QLTRSRELDE C FAQANDQMEI |
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| 4 |
1100 |
GKSAKQNLDK C YGQIKELNEK |
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| 5 |
1280 |
AEENALQQKA C GSEIMQKKQH |
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| 6 |
135 |
IREMRQMGQP C DAYQKRLLQL |
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| 7 |
1499 |
LIDKETNDRK C LEDENARLQR |
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| 8 |
1589 |
RLKRTASEDS C KRKKLEEELE |
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| 9 |
174 |
ASSKGGGGYT C QSGSGWDEFT |
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| 10 |
1805 |
SNRIQESKNQ C TQVVQERESL |
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| 11 |
1957 |
YGSHRETQTE C EWTVDTSKLV |
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| 12 |
1983 |
KKVTAMQLYE C QLIDKTTLDK |
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| 13 |
2259 |
RIKDFLQGSS C IAGIYNETTK |
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| 14 |
2442 |
RCIKDEETGL C LLPLKEKKKQ |
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| 15 |
2656 |
TGQRLLEAQA C TGGIIHPTTG |
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| 16 |
2776 |
DTSSYAKILT C PKTKLKISYK |
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| 17 |
289 |
TSREIMWIND C EEEELLYDWS |
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| 18 |
482 |
DQKIVHKGDE C ILKDNNERSK |
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| 19 |
57 |
VITDQNSDGY C QTGTMSRHQN |
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| 20 |
768 |
GVTDGYLNSL C TVRALLQAIL |
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| 21 |
78 |
QNTIQELLQN C SDCLMRAELI |
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| 22 |
798 |
EARLTEEETV C LDLDKVEAYR |
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| 23 |
899 |
RNYRDNYQAF C KWLYDAKRRQ |
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