Protein Name:
Membrane cofactor protein
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UniprotKB/SwissProt ID: P15529 (P15529)
Gene Name:
CD46
Organism: Homo sapiens (Human)
Function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3 (Microbial infection) Acts as a receptor for cultured Measles virus (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6 (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P15529
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
256 |
FYYKATVMFE C DKGFYLDGSD |
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