Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
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UniprotKB/SwissProt ID: P15170 (P15170)
Gene Name:
GSPT1
Organism: Homo sapiens (Human)
Function: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P15170
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
261 |
NPKKDIHFMP C SGLTGANLKE |
CCCCCCCCCC C CCCCCHHHHH |
3.19% |
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| 2 |
276 |
GANLKEQSDF C PWYIGLPFIP |
CCCCCCCCCC C CCCCCHHHHH |
2.51% |
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| 3 |
327 |
VLGKLESGSI C KGQQLVMMPN |
CCCCCCCCCC C CCCCCHHHHH |
4.31% |
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| 4 |
387 |
GFILCDPNNL C HSGRTFDAQI |
CCCCCCCCCC C CCCCCHHHHH |
2.33% |
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| 5 |
453 |
RPRFVKQDQV C IARLRTAGTI |
CCCCCCCCCC C CCCCCHHHHH |
1.35% |
19483679
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| 6 |
464 |
IARLRTAGTI C LETFKDFPQM |
CCCCCCCCCC C CCCCCHHHHH |
2.56% |
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