Protein Name:
Microtubule-associated protein 1B
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UniprotKB/SwissProt ID: P14873 (P14873)
Gene Name:
Map1b
Organism: Mus musculus (Mouse)
Function: Required for proper microtubule dynamics. Plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm. Synapse. Cell projection, dendritic spine. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P14873
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1224 |
FSKSALRDAY C SEEKELKASA |
CCEEEEEECC C CCCCCCCCCC |
4.41% |
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| 2 |
1913 |
EKTERTIKSP C DSGYSYETIE |
CCEEEEEECC C CCCCCCCCCC |
9.32% |
22178444
19101475
|
| 3 |
1936 |
IKTPEDGGYT C EITEKTTRTP |
CCEEEEEECC C CCCCCCCCCC |
2.4% |
22178444
19101475
|
| 4 |
2037 |
TTRSPDTSAY C YETMEKITKT |
CCEEEEEECC C CCCCCCCCCC |
2.18% |
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| 5 |
2061 |
STYSYETSDR C YTTEKKSPSE |
CCEEEEEECC C CCCCCCCCCC |
4.2% |
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| 6 |
2357 |
PPGLPVYLDL C YIPNHSNSKN |
CCEEEEEECC C CCCCCCCCCC |
2.63% |
22178444
17704770
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| 7 |
2460 |
VVMQDESFPA C KIEL------ |
CCEEEEEECC C CCCCCCCCCC |
4.67% |
17704770
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