Protein Name:
Matrix metalloproteinase-9
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UniprotKB/SwissProt ID: P14780 (P14780)
Gene Name:
MMP9
Organism: Homo sapiens (Human)
Function: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:12879005, PubMed:1480034, PubMed:2551898). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P14780
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
99 |
ATLKAMRTPR C GVPDLGRFQT |
CCCHHHHHHH H HHHHHHHHCH |
7.3% |
22178444
12183632
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