Protein Name:
Endoplasmin
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UniprotKB/SwissProt ID: P14625 (P14625)
Gene Name:
HSP90B1
Organism: Homo sapiens (Human)
Function: ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P14625
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
138 |
GNEELTVKIK C DKEKNLLHVT |
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| 2 |
576 |
IYLTEPVDEY C IQALPEFDGK |
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| 3 |
645 |
VVSQRLTESP C ALVASQYGWS |
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