Protein Name:
Lysosome-associated membrane glycoprotein 1
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UniprotKB/SwissProt ID: P14562 (P14562)
Gene Name:
Lamp1
Organism: Rattus norvegicus (Rat)
Function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome membrane. Endosome membrane. Late endosome membrane. Cell membrane. Cytolytic granule membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P14562
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
260 |
INPSDKYSGT C GAQLVTLKVG |
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| 2 |
328 |
LQASVGNSYK C NSEEHIFVSK |
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