Protein Name:
Calreticulin
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UniprotKB/SwissProt ID: P14211 (P14211)
Gene Name:
Calr
Organism: Mus musculus (Mouse)
Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:20880849, PubMed:21652723). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Cytolytic granule. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P14211
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
FTVKHEQNID C GGGYVKLFPS |
CCCHHHHHHH H HHHHHHCHHH |
4.9% |
24926564
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| 2 |
137 |
EYNIMFGPDI C GPGTKKVHVI |
CCCHHHHHHH H HHHHHHCHHH |
7.59% |
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| 3 |
163 |
KNVLINKDIR C KDDEFTHLYT |
CCCHHHHHHH H HHHHHHCHHH |
6.07% |
22178444
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