Protein Name:
Small ribosomal subunit protein uS2
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UniprotKB/SwissProt ID: P14206 (P14206)
Gene Name:
Rpsa
Organism: Mus musculus (Mouse)
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P14206
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
148 |
SYVNLPTIAL C NTDSPLRYVD |
CCCCCCHHHC C HHHHHHHHHH |
3.68% |
21278135
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| 2 |
163 |
PLRYVDIAIP C NNKGAHSVGL |
CCCCCCHHHC C HHHHHHHHHH |
7.77% |
24895380
24926564
21278135
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