dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Malate dehydrogenase, cytoplasmic

UniprotKB/SwissProt ID: P14152 (P14152)

Gene Name: Mdh1

Organism: Mus musculus (Mouse)

Function: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:

InterPro ID	Domain Name
IPR001557	L-lactate/malate_DH
IPR022383	Lactate/malate_DH_C
IPR001236	Lactate/malate_DH_N
IPR015955	Lactate_DH/Glyco_Ohase_4_C
IPR001252	Malate_DH_AS
IPR011274	Malate_DH_NAD-dep_euk
IPR010945	Malate_DH_type2
IPR036291	NAD(P)-bd_dom_sf

The S-nitrosylation sites of P14152

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	PubMed ID
1	137	IVVGNPANTN C LTASKSAPSI	CCCCEEEEEE C CHHHHHHHHH	3.17%	24895380 22588120 16418269 19101475 21278135
2	154	APSIPKENFS C LTRLDHNRAK	CCCCEEEEEE C CHHHHHHHHH	3.83%	24895380 22588120 21278135

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