UniprotKB/SwissProt ID: P13808 (P13808)
Gene Name:
Slc4a2
Organism: Mus musculus (Mouse)
Function: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:12958022, PubMed:18971331, PubMed:23341620, PubMed:2371270, PubMed:24515893). Plays an important role in osteoclast differentiation and function (PubMed:18971331, PubMed:23341620). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (PubMed:23341620). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (PubMed:24515893) Plays a critical role in male fertility and spermiogenesis Plays a critical role in male fertility and spermiogenesis Plays a critical role in male fertility and spermiogenesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Basolateral cell membrane
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