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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Electron transfer flavoprotein subunit alpha, mitochondrial

UniprotKB/SwissProt ID: P13804 (P13804)

Gene Name: ETFA

Organism: Homo sapiens (Human)

Function: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR014730 ETF_a/b_N
IPR001308 ETF_a/FixB
IPR033947 ETF_alpha_N
IPR014731 ETF_asu_C
IPR018206 ETF_asu_C_CS
IPR014729 Rossmann-like_a/b/a_fold

The S-nitrosylation sites of P13804

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 109 TQKQFNYTHI C AGASAFGKNL  CCCCCCCHHH H HHHHHHHHHC  1.91%
2 155 VRTIYAGNAL C TVKCDEKVKV  CCCCCCCHHH H HHHHHHHHHC  3.69%
3 53 AATRLGGEVS C LVAGTKCDKV  CCCCCCCHHH H HHHHHHHHHC  4.24% 19483679
4 68 TKCDKVAQDL C KVAGIAKVLV  CCCCCCCHHH H HHHHHHHHHC  4.48%