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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor 2
UniprotKB/SwissProt ID: P13639 (P13639)

Gene Name: EEF2

Organism: Homo sapiens (Human)

Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR041095 EFG_II
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd
IPR000795 T_Tr_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR005517 Transl_elong_EFG/EF2_IV
The S-nitrosylation sites of P13639
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 131 VTDGALVVVD C VSGVCVQTET  CCCCCHHHHH H HHHHCCCCCC  1.45%
2 136 LVVVDCVSGV C VQTETVLRQA  CCCCCHHHHH H HHHHCCCCCC  1.83%
3 290 PEGKKLPRTF C QLILDPIFKV  CCCCCHHHHH H HHHHCCCCCC  2.96% 19483679
25040305
4 369 PSPVTAQKYR C ELLYEGPPDD  CCCCCHHHHH H HHHHCCCCCC  3.81% 22178444
20140087
5 388 DDEAAMGIKS C DPKGPLMMYI  CCCCCHHHHH H HHHHCCCCCC  9.85%
6 41 GKSTLTDSLV C KAGIIASARA  CCCCCHHHHH H HHHHCCCCCC  2.79% 2212679
19483679
20140087
22126794
22178444
19101475
7 466 RYVEPIEDVP C GNIVGLVGVD  CCCCCHHHHH H HHHHCCCCCC  7%
8 567 CLKDLEEDHA C IPIKKSDPVV  CCCCCHHHHH H HHHHCCCCCC  3.22% 22178444
19483679
16648260
9 591 ETVSEESNVL C LSKSPNKHNR  CCCCCHHHHH H HHHHCCCCCC  3.34% 19483679
10 651 WDVAEARKIW C FGPDGTGPNI  CCCCCHHHHH H HHHHCCCCCC  3% 22178444
20140087
11 67 TDTRKDEQER C ITIKSTAISL  CCCCCHHHHH H HHHHCCCCCC  2.95% 19483679
12 693 FQWATKEGAL C EENMRGVRFD  CCCCCHHHHH H HHHHCCCCCC  6.46%
13 728 GGQIIPTARR C LYASVLTAQP  CCCCCHHHHH H HHHHCCCCCC  2.58% 19483679
25040305
37478858
14 751 MEPIYLVEIQ C PEQVVGGIYG  CCCCCHHHHH H HHHHCCCCCC  5%
15 812 SNTGGQAFPQ C VFDHWQILPG  CCCCCHHHHH H HHHHCCCCCC  3.16%