UniprotKB/SwissProt ID: P13497 (P13497)
Gene Name:
BMP1
Organism: Homo sapiens (Human)
Function: Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307) Plays an important role in bone repair by acting as a coactivator of BMP7
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted. Secreted
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