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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ribonuclease inhibitor
UniprotKB/SwissProt ID: P13489 (P13489)

Gene Name: RNH1

Organism: Homo sapiens (Human)

Function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR041302 LRR_RI_cap
IPR050637 NLRP_innate_immun_reg
The S-nitrosylation sites of P13489
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 102 LQNCCLTGAG C GVLSSTLRTL  CCCCCCCCCC C CHHHCCHHHH  3.18%
2 152 CRLEKLQLEY C SLSAASCEPL  CCCCCCCCCC C CHHHCCHHHH  2.11%
3 159 LEYCSLSAAS C EPLASVLRAK  CCCCCCCCCC C CHHHCCHHHH  5.53%
4 199 VLCQGLKDSP C QLEALKLESC  CCCCCCCCCC C CHHHCCHHHH  9.26%
5 209 CQLEALKLES C GVTSDNCRDL  CCCCCCCCCC C CHHHCCHHHH  3.57%
6 216 LESCGVTSDN C RDLCGIVASK  CCCCCCCCCC C CHHHCCHHHH  4.26%
7 220 GVTSDNCRDL C GIVASKASLR  CCCCCCCCCC C CHHHCCHHHH  4.02%
8 248 KLGDVGMAEL C PGLLHPSSRL  CCCCCCCCCC C CHHHCCHHHH  1.57% 22178444
20140087
9 266 SRLRTLWIWE C GITAKGCGDL  CCCCCCCCCC C CHHHCCHHHH  2.61%
10 30 WAELLPLLQQ C QVVRLDDCGL  CCCCCCCCCC C CHHHCCHHHH  1.82%
11 313 LLCETLLEPG C QLESLWVKSC  CCCCCCCCCC C CHHHCCHHHH  6.46%
12 362 RLEDAGVREL C QGLGQPGSVL  CCCCCCCCCC C CHHHCCHHHH  2.3%
13 38 QQCQVVRLDD C GLTEARCKDI  CCCCCCCCCC C CHHHCCHHHH  4.86% 22178444
20140087
14 387 LADCDVSDSS C SSLAATLLAN  CCCCCCCCCC C CHHHCCHHHH  3.57%
15 409 SLRELDLSNN C LGDAGILQLV  CCCCCCCCCC C CHHHCCHHHH  5.41% 22178444
16 45 LDDCGLTEAR C KDISSALRVN  CCCCCCCCCC C CHHHCCHHHH  6.31%
17 75 SNELGDVGVH C VLQGLQTPSC  CCCCCCCCCC C CHHHCCHHHH  2.8% 22178444
18 85 CVLQGLQTPS C KIQKLSLQNC  CCCCCCCCCC C CHHHCCHHHH  4.78% 22178444