Protein Name:
Protein Cripto
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UniprotKB/SwissProt ID: P13385 (P13385)
Gene Name:
CRIPTO
Organism: Homo sapiens (Human)
Function: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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