UniprotKB/SwissProt ID: P13285 (P13285)
Gene Name:
LMP2
Organism: Epstein-Barr virus (strain B95-8) (HHV-4)
Function: Maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs (By similarity) May be a negative regulator of isoform LMP2A
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Host cell membrane. Host endomembrane system. Host cytoplasm, host perinuclear region
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