Protein Name:
Gamma-interferon-inducible lysosomal thiol reductase
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UniprotKB/SwissProt ID: P13284 (P13284)
Gene Name:
IFI30
Organism: Homo sapiens (Human)
Function: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR004911
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Interferon-induced_GILT |
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The S-nitrosylation sites of P13284
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
162 |
FEDMERSLPL C LQLYAPGLSP |
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| 2 |
237 |
QLYQGKKPDV C PSSTSSLRSV |
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