Protein Name:
Islet amyloid polypeptide
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UniprotKB/SwissProt ID: P12969 (P12969)
Gene Name:
Iapp
Organism: Rattus norvegicus (Rat)
Function: Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (PubMed:35324283). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (PubMed:35324283)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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