Protein Name:
Neuroendocrine protein 7B2
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UniprotKB/SwissProt ID: P12961 (P12961)
Gene Name:
Scg5
Organism: Mus musculus (Mouse)
Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR007945
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Secretogranin_V |
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The S-nitrosylation sites of P12961
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
130 |
CPLGKTADDG C LENAPDTAEF |
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