Protein Name:
Xaa-Pro dipeptidase
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UniprotKB/SwissProt ID: P12955 (P12955)
Gene Name:
PEPD
Organism: Homo sapiens (Human)
Function: Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P12955
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
183 |
NTILHPEIVE C RVFKTDMELE |
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| 2 |
230 |
YELESLFEHY C YSRGGMRHSS |
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| 3 |
482 |
VEEIEACMAG C DKAFTPFSGP |
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| 4 |
58 |
LQGGEETQRY C TDTGVLFRQE |
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| 5 |
82 |
HWAFGVTEPG C YGVIDVDTGK |
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