Protein Name:
Alpha-actinin-1
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UniprotKB/SwissProt ID: P12814 (P12814)
Gene Name:
ACTN1
Organism: Homo sapiens (Human)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P12814
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
154 |
TSAKEGLLLW C QRKTAPYKNV |
CCCCCCCCCC C CCCCHHHCCH |
2.57% |
25040305
|
| 2 |
332 |
LHKPPKVQEK C QLEINFNTLQ |
CCCCCCCCCC C CCCCHHHCCH |
5.7% |
20140087
19483679
18335467
37478858
|
| 3 |
370 |
MVSDINNAWG C LEQVEKGYEE |
CCCCCCCCCC C CCCCHHHCCH |
2.36% |
|
| 4 |
41 |
KQQRKTFTAW C NSHLRKAGTQ |
CCCCCCCCCC C CCCCHHHCCH |
3.29% |
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| 5 |
480 |
PSVNARCQKI C DQWDNLGALT |
CCCCCCCCCC C CCCCHHHCCH |
4.02% |
20140087
|
| 6 |
774 |
GTLGPEEFKA C LISLGYDIGN |
CCCCCCCCCC C CCCCHHHCCH |
3.41% |
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| 7 |
860 |
RELPPDQAEY C IARMAPYTGP |
CCCCCCCCCC C CCCCHHHCCH |
1.15% |
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