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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Fatty acid synthase
UniprotKB/SwissProt ID: P12785 (P12785)

Gene Name: Fasn

Organism: Rattus norvegicus (Rat)

Function: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029058 AB_hydrolase_fold
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase_dom
IPR016035 Acyl_Trfase/lysoPLipase
IPR049391 FAS_pseudo-KR
IPR011032 GroES-like_sf
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR032821 PKS_assoc
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR042104 PKS_dehydratase_sf
IPR020807 PKS_DH
IPR049552 PKS_DH_N
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR049900 PKS_mFAS_DH
IPR050091 PKS_NRPS_Biosynth_Enz
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases_sf
IPR001031 Thioesterase
IPR016039 Thiolase-like
The S-nitrosylation sites of P12785
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1464 RKEPGGHRIR C ILLSNLSSTS  CCEEEEECCC C CCCCCCCHHH  2.09%
2 2004 LNLDRATREA C PELDYFVAFS  CCEEEEECCC C CCCCCCCHHH  2%
3 2085 GGTLPQRISS C MEVLDLFLNQ  CCEEEEECCC C CCCCCCCHHH  1.84%
4 2353 QSYRAKLTPG C EAEAEAEAIC  CCEEEEECCC C CCCCCCCHHH  4.76%
5 2462 LGADYNLSQV C DGKVSVHIIE  CCEEEEECCC C CCCCCCCHHH  4.41%