Protein Name:
Creatine kinase B-type
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UniprotKB/SwissProt ID: P12277 (P12277)
Gene Name:
CKB
Organism: Homo sapiens (Human)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Mitochondrion. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P12277
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
141 |
VRTGRSIRGF C LPPHCSRGER |
CCCCCCCCCE E CCCCCCCCCC |
6.58% |
37478858
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| 2 |
146 |
SIRGFCLPPH C SRGERRAIEK |
CCCCCCCCCE E CCCCCCCCCC |
3.51% |
37478858
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| 3 |
254 |
GNMKEVFTRF C TGLTQIETLF |
CCCCCCCCCE E CCCCCCCCCC |
2.38% |
19483679
25040305
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| 4 |
283 |
WNPHLGYILT C PSNLGTGLRA |
CCCCCCCCCE E CCCCCCCCCC |
2.89% |
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| 5 |
74 |
PGHPYIMTVG C VAGDEESYEV |
CCCCCCCCCE E CCCCCCCCCC |
1.32% |
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