Protein Name:
Inosine-5'-monophosphate dehydrogenase 2
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UniprotKB/SwissProt ID: P12268 (P12268)
Gene Name:
IMPDH2
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P12268
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
140 |
VFEAKARHGF C GIPITDTGRM |
CCCEEECCCC C CCCCCCCCHH |
5.98% |
22178444
19483679
37478858
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| 2 |
173 |
IDFLKEEEHD C FLEEIMTKRE |
CCCEEECCCC C CCCCCCCCHH |
4.53% |
22178444
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| 3 |
246 |
ASKDAKKQLL C GAAIGTHEDD |
CCCEEECCCC C CCCCCCCCHH |
4.78% |
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| 4 |
331 |
LRVGMGSGSI C ITQEVLACGR |
CCCEEECCCC C CCCCCCCCHH |
2.7% |
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| 5 |
339 |
SICITQEVLA C GRPQATAVYK |
CCCEEECCCC C CCCCCCCCHH |
4.09% |
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