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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Histidine--tRNA ligase, cytoplasmic
UniprotKB/SwissProt ID: P12081 (P12081)

Gene Name: HARS1

Organism: Homo sapiens (Human)

Function: Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR015807 His-tRNA-ligase
IPR041715 HisRS-like_core
IPR004516 HisRS/HisZ
IPR033656 HisRS_anticodon
IPR009068 uS15_NS1_RNA-bd_sf
IPR000738 WHEP-TRS_dom
The S-nitrosylation sites of P12081
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 224 RRILDGMFAI C GVSDSKFRTI   
2 235 GVSDSKFRTI C SSVDKLDKVS   
3 379 MFDPKGRKVP C VGLSIGVERI   
4 455 NPKLLNQLQY C EEAGIPLVAI